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Dr Hviid said: Because of the high cost, we assume that compliance is very high among the women prescribed GLP-1 RAs. In an invited commentary accompanying the paper, Drs Yeyi Zhu and Monique Hedderson, from Kaiser Permanente Northern California and the Center for Upstream Prevention of Adiposity and Diabetes Mellitus, in Pleasanton, California, USA, write that the studys findings complement and extend an emerging evidence base on the reproductive safety of GLP-1 RAs. They continue: For clinicians, the study by Hviid et al (2026) may inform preconception and early pregnancy counseling

Part of taking a GLP-1 means being mindful about what your body needsgetting enough protein to protect muscle, choosing fiber-rich carbs for digestion and energy, drinking plenty of water, and eating smaller portions that wont overwhelm your system

A landmark meta-analysis found that weight reduction of 5-10% resulted in spontaneous ovulation restoration in 55-100% of women with anovulation related to obesity

10.2217/pgs.13.135 Pharmacogenomics 159 Mirosevic SkvrceN.Macolic SarinicV.SimicI.GanociL.Muacevic KatanecD.BozinaN

The six most common causes of GLP-1 fatigue are: Eating too few calories Low protein intake and muscle loss Dehydration and low electrolytes Metabolic adaptation and energy conservation Blood sugar fluctuations Poor sleep quality (often compounded by under-eating) Cause 1: Eating Too Few Calories This is the most common driver of fatigue in GLP-1 users